Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
3 results
Cited 4 times since 2014 (0.4 per year) source: Scopus
Perfusion, Volume 30, Issue 4, 1 1 2014, Pages 295-301 Sevoflurane-enriched blood cardioplegia: the intramyocardial delivery of a volatile anesthetic. van der Baan A, Kortekaas KA, van Es E, Meier S, Klautz RJ, Engbers FH
Myocardial ischemia/reperfusion injury is a major problem in cardiac surgery, characterized by an enhanced inflammatory response postoperatively. Sevoflurane has anti-inflammatory effects and may attenuate this injury. This study describes a novel approach to using sevoflurane as a local anti-inflammatory drug and not as an anesthetic. Therefore, a pediatric oxygenator with a sevoflurane vaporizer was integrated into the blood cardioplegia system of an adult bypass system. In addition, a gas ble... Abstract
Cited 22 times since 2014 (2.2 per year) source: Scopus
British journal of anaesthesia, Volume 112, Issue 6, 3 1 2014, Pages 1005-1014 Cardiospecific sevoflurane treatment quenches inflammation but does not attenuate myocardial cell damage markers: a proof-of-concept study in patients undergoing mitral valve repair. Kortekaas KA, van der Baan A, Aarts LP, Palmen M, Cobbaert CM, Verhagen JC, Engbers FH, Klautz RJ, Lindeman JH
Background: Inflammation is considered a key mediator of complications after cardiac surgery. Sevoflurane has been shown to quench inflammation and to provide cardioprotection in preclinical studies. Clinical studies using sevoflurane confirm this effect on inflammation but do not consistently show clinical benefits. This paradox may indicate that the contribution of inflammation to postoperative sequalae is less than commonly thought or that systemic doses are too low in their local concentrati... Abstract
Cited 566 times since 2006 (31.6 per year) source: EuropePMC
Circulation, Volume 113, Issue 23, 5 1 2006, Pages 2744-2753 Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress. Cheng C, Tempel D, van Haperen R, van der Baan A, Grosveld F, Daemen MJ, Krams R, de Crom R
Background: Atherosclerotic lesions are predominantly observed in curved arteries and near side branches, where low or oscillatory shear stress patterns occur, suggesting a causal connection. However, the effect of shear stress on plaque vulnerability is unknown because the lack of an appropriate in vivo model precludes cause-effect studies. Methods and results: We developed a perivascular shear stress modifier that induces regions of lowered, increased, and lowered/oscillatory (ie, with vortice... Abstract